Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with FKBP
نویسندگان
چکیده
Ana María Gómez, PhD 1 , Angélica Rueda, PhD 1 , Yannis Sainte-Marie, PhD 2 , Laetitia Pereira PhD 1 , Spyros Zissimopoulos PhD 3 , Xinsheng Zhu, PhD 4 , Roxane Schaub, MD 5 , Emeline Perrier, PhD 1 , Romain Perrier PhD 1 , Céline Latouche, MS 2 , Sylvain Richard, PhD 1 , Marie-Christine Picot, MD PhD 5 , Frederic Jaisser, MD PhD 2 , F Anthony Lai, PhD 3 , Héctor H Valdivia, MD PhD 4 and Jean-Pierre Benitah, PhD 1
منابع مشابه
Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.
BACKGROUND The mineralocorticoid pathway is involved in cardiac arrhythmias associated with heart failure through mechanisms that are incompletely understood. Defective regulation of the cardiac ryanodine receptor (RyR) is an important cause of the initiation of arrhythmias. Here, we examined whether the aldosterone pathway might modulate RyR function. METHODS AND RESULTS Using the whole-cell...
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The calcium release channels (CRC)/ryanodine receptors of skeletal (Sk) and cardiac (C) muscle sarcoplasmic reticulum (SR) are hetero-oligomeric complexes with the structural formulas (ryanodine recepter (RyR)1 protomer)4(FKBP12)4 and (RyR2 protomer)4(FKBP12.6)4, respectively, where FKBP12 and FKBP12.6 are isoforms of the 12-kDa receptor for the immunosuppressant drug FK506. The sequence simila...
متن کاملبررسی اثر مهار گیرنده رایانیدینی(RYR) بر فعالیت پیسمیکری
Background & Aim: The role of ryanodine receptor(RYR) on pacemaker activity of heart cells is controversial. Some investigators have suggested that it is obligatory, while others believe it is partial and not obligatory. The principle aim of this study was once more to characterize the role of ryanodine receptor(RyR) on the pacemaker activity of the sinoatrial node(SAN) and the atrioventric...
متن کاملDisparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.
The FK506-binding proteins (FKBP12 and FKBP12.6; also known as FKBP1A and FKBP1B, respectively) are accessory subunits of the ryanodine receptor (RyR) Ca(2+) release channel. Aberrant RyR2-FKBP12.6 interactions have been proposed to be the underlying cause of channel dysfunction in acquired and inherited cardiac disease. However, the stoichiometry of the RyR2 association with FKBP12 or FKBP12.6...
متن کاملModulation of ryanodine receptor Ca2+ channels (Review).
Ryanodine-sensitive Ca2+ release channels (ryanodine receptors, RyRs) play a crucial role in the mobilization of Ca2+ from the sarcoplasmic reticulum (SR) during the excitation-contraction coupling of muscle cells. In skeletal muscle, depolarization of transverse tubules activates the RyR, whereas in cardiac muscle, a Ca2+ influx through an L-type Ca2+ channel activates the RyR. The RyR is also...
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